Thursday, July 25, 2019

Larix International Cardiology Conferences

Larix International is a group of ranking publishers and organizer’s for scientific conferences around the globe nesting well-known Doctors, Engineers, Scientists, and Industrialists. Larix is a self-functioning, independent organization wholly focused on arranging conferences in multi-disciplines of research on various science fields. The conferences are administered by global influential scientists and scientific excellence. We are even open for the upcoming scientists and scholars, who are in need of a platform to give their voice a much needed larger volume.

WORLD CONGRESS ON CARDIOLOGY AND CRITICAL CARE (World Cardiology Congress 2019) is going to be organized in the beautiful city of Singapore on July 25-26, 2019 at Holiday Inn Atrium, primarily focusing on the theme “Novel insights in cardiology”.


Cardiology is a medical specialty and a branch of internal medicine concerned with disorders of the heart. It deals with the diagnosis and treatment of such conditions as congenital heart defects, coronary artery disease, electrophysiology, heart failure, and valvular heart disease. Subspecialties of the cardiology field include cardiac electrophysiology, echocardiography, interventional cardiology, and nuclear cardiology. There is a range of disorders of the cardiovascular system that are treated and studied under the field of cardiology. Among them is an acute coronary syndrome, which encompasses the broad range of myocardial infarction symptoms. Angina pectoris, atherosclerosis, coronary heart disease, and restenosis are other common disorders. Broader categories of disorders in the field of cardiology include cardiac arrest; disorders of the myocardium, or the muscle of the heart, which include varieties of cardiomyopathy; disorders of the pericardium, or the outer lining of the heart, which include types of pericarditis; disorders of the heart valves, including the aortic valve, the mitral valve, the pulmonary valve and the tricuspid valve; congenital heart defects, which range from atrial septal defect to ventricular septal defect; diseases of the blood vessels, or vascular diseases, which includes aneurysm, deep vein thrombosis, varicose veins, vasculitis and diseases of other blood vessels.


Clinical and Interventional, Cardiology, Cardiovascular diseases, Hypertension, Cardiomyopathies
Atherosclerosis, Arrhythmia, Heart stroke, Pediatric Cardiology, Vascular Biology, Obesity and Heart, Cardiac Imaging, Echocardiography, Cardiac Transplantation, Pediatric Critical Care, Cardiac Intensive Care Unit, Cardiac Regeneration, Cardiac Surgery, Cardiology – Future Medicine, Trans-aortic valve replacement, Nuclear Cardiology.

Cardiologists; Cardiac Surgeons; University Professors; Various Societies and their members; Institutes-Medical Schools Students; Research Scholars; Business Entrepreneurs; Pharmaceutical representatives, Medical Device Manufacturers.

Join us:

· To Build networking Opportunities.

· You’re Knowledge Base.

· Expand Your Resources.

· Meet Experts & Influencers Face to Face.

· Learning In a New Space.

· Break Out of Your Comfort Zone.

· New Tips & Tactics.

· Greater Focus.

· The Serendipity of the Random Workshop.

Friday, May 24, 2019

Gene therapy for heart failure: how does gene therapy work? 

Gene therapy introduces a genetic material (DNA) into the cells to make a beneficial protein. In heart disease, gene therapy may be able to place a normal copy of the gene into the human cell to change how the cell works with the end goal of correcting the disease. To insert the gene into a cell, gene therapy uses a vector or carrier to introduce the gene into the human cell. Non viral vectors are relatively easy to produce and consist of plasmid (DNA that can reproduce). The vector lets the gene take a piggyback ride on it to reach the diseased cells. Once there, it is absorbed into the cells to help stimulate the body to make more beneficial protein. They are delivered by direct administration, as in this example of the patient treated in the STOP-HF JUVENTAS trial. 

In this case, stroma cell-derived Factor-1 (SDF-1) was injected at multiple sites inside the left ventricle. By avoiding exposure to blood it prevents some weakening of the vector and does not affect other organs as much. Viral vectors or carriers have become the preferred method of delivery of gene therapy because of their high efficiency and capability. The adeno-associated virus (AAV) has emerged as the preferred factor because it is safe and can have a long term effect. This AAV virus is not known to cause disease in humans. Delivery of genetic material through the circulation can be accomplished either by direct injection through the coronaries. It can also be injected through bypass graft to the coronaries or a retrograde infusion through the coronary sinus into the venous system of the heart. 

Gene therapy targeting calcium regulating protein: 

Heart failure is characterized by multiple defects in handling the calcium involved in excitation and contraction of the heart cells. Abnormal adjustment of calcium inside the cell can be attributed in part to decreased activity of an enzyme called SERCA2a. In heart failure, there are lower levels of this enzyme in heart muscle cells which makes the heart not contract as much as it should. . Increasing the enzyme in the heart muscle cells of animals with heart failure improves heart function. Preliminary data showed that intracoronary infusion of (AAV1) adeno-associated virus delivering the gene of this enzyme to the heart improved symptoms, functional status and LV function in patients with advanced heart failure.

CUPID phase 2b trial was a multicenter, double-blind, placebo control, randomized study of AAV1/SERCA2a (attenuated virus and the gene) in patients with advanced heart failure. Patients ages 18-80 with stable class 2-4 heart failure with ischemic or nonischemic cardiomyopathy were enrolled. The following images depict the coronary angiogram of one of our patient at CardiologyPC. He is a 59-year-old patient who underwent bypass surgery 12 years prior and a biV-ICD 3 years prior to enrollment. The patients was hospitalized 5 months before his enrollment in CUPID because of heart failure decompensation.

Thursday, April 18, 2019

A healthy food for a wealthy mood!

Junk food, Diet drinks are safe for Children’s ….?

While shift to diet drinks will facilitate cut calories and promote weight loss, specialists advise against regular consumption of beverages with artificial sweeteners throughout childhood. These recommendations were revealed in an exceedingly recent scientific informatory from the yankee Heart Association and replicate a scarcity of proof regarding the semipermanent safety of artificial sweeteners.

Six artificial sweeteners presently approved by the U.S. Food and Drug Administration: sweetener, aspartame, acesulfame-K, sucralose, neotame and advantame. It additionally enclosed knowledge on plant extracts from the stevia plant and monk fruit. These sweeteners included enclosed in nearly all diet or low-calorie beverages. It’s calculable that nineteen of drinks consumed by kids and thirty second of drinks consumed by adults contain artificial sweeteners.

The kids at home: Their 1st stop grab a sweet drink from the icebox. It's one in all many unhealthy habits that have designed a nation of overweight children. Once it involves their health, kids and sweet beverages square measure merely a nasty match.
Unless artificial, low-calorie sweeteners square measure used, all sweet drinks like fruitades, fruit drinks, sports drinks, and sugared seasoned drinks pack calories. One study found that women who got a lot of sweet drinks before age nine gained additional weight by age thirteen. They additionally had prediabetes risk factors massive area, high vital sign, and low HDL good cholesterol.

Indeed, among overweight kids and adolescents, pediatricians are seeing health issues they accustomed realize solely in adults high vital sign, high sterol, and high acylglycerol levels, that are risk factors for Diabetes, cardiopathy, and stroke.

Small differences can make a difference to your health. Eating healthy means following a healthy eating pattern that includes a variety of nutritious food. It is important to count your calories. Healthy eating is something everyone knows they should do. But very few people follow it.
Healthy eating is not stopping yourself from eating the foods you love. It is all about feeling great, improving your health and boosting your mood.

Eating healthy diet doesn’t have to be overly complicated. Eating food that is as close as possible to the way nature made it can make a very big difference to the way you look, think and feel. We all need a balance of protein, fat, carbohydrates, fiber, vitamins and minerals in our diets to maintain a healthy body.

A better approach is to make a few small changes at a time. When cutting back on unhealthy foods in your diet it is important to replace them with healthy foods. The healthier the food you eat the better you will feel after a meal. The more junk you eat, the more likely you feel uncomfortable and heavy.
Drinking plenty of water also is very important for staying healthy and fit. Water helps flush our systems of waste products and toxins. Dehydration causes us tiredness, low energy and headaches. Staying hydrated is also very important.

Tuesday, April 2, 2019

HEART ATTACK/STROKE: An electrical problem of the HEART!

Heart Attack:
A heart attack or myocardial infarction (MI) happens when a problem somewhere in the body reduces or blocks blood flow to a coronary artery. This can stop the flow of blood to the heart.

Coronary arteries supply the heart muscle with blood flow. They can become narrow if substances such as fat and cholesterol build up. The name of these substances is plaque. Plaque usually builds up over several years. If pieces of plaque break off in a heart artery, a blood clot can form around it. This can stop the normal blood flow from reaching the heart muscle. If this happens, part of the heart muscle does not get enough oxygen. This part begins to die if the blockage does not receive treatment quickly. Scar tissue begins to replace healthy heart tissue. When there is damage or death to the heart muscle due to a lack of oxygen and nutrients, a heart attack can result.

A stroke occurs when low blood supply to the brain stops the brain tissue from receiving oxygen and other essential nutrients. It can happen when a blood vessel that carries oxygen and nutrients to the brain: bursts or is blocked by a clot
Any brain cells that do not receive oxygen begin to die. This can happen within minutes. Sometimes a person will have a temporary clot. This can lead to an ischemic attack (TIA), or "mini-stroke."

A brain aneurysm is a bulge in an artery that can burst. It can lead to a stroke. The symptoms of a stroke and an aneurysm can be similar, but they may require different treatment.


Blocked arteries and blood clots can cause both heart attacks and strokes. So, their treatment may be similar in several ways. In such conditions, thrombolytics help dissolve the blood clot and restore blood flow to the affected organ, reducing future plaque buildup in the arteries, lowering blood pressure or cholesterol, reducing blood clots.

Saturday, March 16, 2019

Heart Transplantation

Heart Transplantation: A surgery to replace the diseased heart with the healthy one!!

Why Heart Transplant?

Heart attack (myocardial infarction or MI)
Viral infection of the heart muscle
High blood pressure
Heart valve disease
Heart defects present at birth (congenital)
Irregular heartbeats (arrhythmias)
High blood pressure in the lungs (pulmonary hypertension)
Alcoholism or drug abuse
Chronic lung diseases, such as emphysema or chronic obstructive pulmonary disease (COPD)
Heart muscle is enlarged, thick, and stiff (cardiomyopathy)
Low red blood cell count (anemia)


Blood clots
Bleeding during and after the surgery
Coronary Allograft Vasculopathy
Kidney Failure


After heart transplant, five year survival averages about 50%-60%. One year survival averages about 85%-90%.

Thursday, March 7, 2019

Its never too late to start eating Healthier foods!

Limit unhealthy fats and daily physical exercise..

A diet rich in saturated fats can drive up total cholesterol and tip the balance toward more harmful LDL cholestrol, which prompts blockages to form in arteries in the heart and elsewhere in the body.

The foods that best protect against heart disease include:

Oily fish, some vegetables oils, fruit and vegetables, fiber, legumes and soy, nuts and seeds, foods containing vitamin E, garlic, and foods enriched with plant sterols.

Join us for professional development, latest innovations, networking, and opportunity to meet, hear and learn from the best in Cardiology.

Attend the Innovative Sessions in Cardiology!!

Submit your Abstracts!!

WCC2019 invites Cardiology professionals, Young researchers, Students, Postdoctoral fellows from around the world to submit abstracts. WCC2019 provide an opportunity to share interdisciplinary perspectives through presenting and attending panel presentations and informally in the encouraging environment.

Participants interested in presenting their abstract at the Congress are invited to submit an abstract for the oral/Posters via the abstract submission system!!


Saturday, March 2, 2019

Atrial Fibrillation

Atrial fibrillation may be a quivery, fluttery heartbeat. It suggests that your heart’s traditional rhythm is out of whack as a result of your blood is not moving well, you are additional probably to possess failure. That is once your heart cannot maintain along with your body’s desires. Blood can even pool within your heart and kind clots. If one gets stuck in your brain, you'll have a stroke.

When erratic or extra electrical signals throw off the normal timing of the heart's pacemaker, causing the heart to beat faster or just quiver. When the heart quivers instead of contracting rhythmically, blood can pool in the atria, and form blood clots. 

Hyperthyroid-induces atrial fibrillation:
*Atrial fibrillation occurs in 5% to 15% of hyperthyroid cases. 
*Class-I Beta blockers are the preferred rate controlling agents during a hyperthyroid state. 
*Non-dihydropyridine calcium channels blockers can aslo be used if beta blockers are not tolerated. *Propanolol specifically inhibits the conversion of T4 to T3 which is more benefit in hyperthyroidism


Blood thinners prevent clots and strokes, slow your heart rate, and control your heart rhythm.

Apixaban (Eliquis), Aspirin, Clopidogrel (Plavix), Dabigatran (Pradaxa), Enoxaparin (Lovenox), Heparin
Rivaroxaban (Xarelto), Warfarin (Coumadin, Jantoven)